IL1R1:IL1:IL1RAP binds MYD88 homodimer Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-05-17 MYD88 is a cytoplasmic adaptor protein that is recruited to the intracellular region of the IL1 receptor complex following IL1 stimulation. MYD88 binds to the complex of the two receptor chains and subsequently to IL-1 receptor-associated kinase 4 (IRAK4). This complex is the minimum required for signaling (Brikos et al. 2007). Pubmed17507369 Pubmed9430229 Reactome Database ID Release 43450133 Reactome, http://www.reactome.org ReactomeREACT_22154 Reviewed: Pinteaux, E, 2010-05-17 MYD88 homodimer IL1R1:IL1:IL1RAP IL1:IL1R1:IL1RAP:MYD88 homodimer