Retention of phospho-Cdc25C:14-3-3 complexes within the cytoplasm Authored: Matthews, L, 2003-08-05 01:10:00 Cdc25C is phosphorylated by Chk1 at ser-216 (Blasina et al.,1999 ) resulting in both inhibition of the Cdc25 phosphatase activity and creation of a 14-3-3 docking site (Peng et al., 1997). Association of 14-3-3 protein is believed to exclude Cdc25C from the nucleus via cytoplasmic retention of the Cdc25C:14-3-3 complex. Pubmed10330186 Pubmed9278512 Pubmed9889122 Reactome Database ID Release 4375022 Reactome, http://www.reactome.org ReactomeREACT_100 phospho-Cdc25C:14-3-3 protein complex