IRAK1 and 4 interact with Pellino1,2 and 3 Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-05-17 IRAK1 and 4 interact with Pellino-1 (Jiang et al. 2003), 2 (Strellow et al. 2003) and 3 (Butler et al. 2005, 2007). Pellinos may act as scaffolding proteins, bringing signaling complexes into proximity. They are E3 ubiquitin ligases capable of ubiquitinating IRAK1, believed to mediate IL-1-stimulated formation of K63-polyubiquitinated IRAK1 in cells.<br><br>Though not clearly demonstrated and therefore not shown here, the current models of IRAK1 involvement suggest it would be within a complex including TRAF6. Pubmed12496252 Pubmed12860405 Pubmed15917247 Pubmed17675297 Pubmed17997719 Reactome Database ID Release 43450690 Reactome, http://www.reactome.org ReactomeREACT_22286 Reviewed: Pinteaux, E, 2010-05-17 has a Stoichiometric coefficient of 2 Pellino 1,2,3 hp-IRAK1, IRAK4 hp-IRAK1:Pellino, IRAK4:Pellino