IRAK1 and 4 can phosphorylate Pellino-1 and 2. Authored: Ray, KP, 2010-05-17 EC Number: 2.7.11 Edited: Jupe, S, 2010-05-17 IRAK1 and 4 can phosphorylate Pellino-1 and -2 and probably -3. Phosphorylation enhances the E3 ligase activity of Pellino-1 in conjunction with several different E2-conjugating enzymes (Ubc13-Uev1a, UbcH4, or UbcH5a/5b). Phosphorylation at any of several different sites or a combination of other sites leads to full activation of Pellino-1 E3 ubiquitin ligase activity.<br><br>Though not shown here, the current models of IRAK1 involvement suggest it is part of a complex that includes TRAF6. Pubmed12860405 Pubmed19264966 Reactome Database ID Release 43450827 Reactome, http://www.reactome.org ReactomeREACT_22325 Reviewed: Pinteaux, E, 2010-05-17 hp-IRAK1:p-Pellino, IRAK4:p-Pellino hp-IRAK1:Pellino, IRAK4:Pellino