tBID activates BAK protein Authored: Gopinathrao, G, 2004-08-18 11:49:08 Pubmed10950869 Reactome Database ID Release 43139895 Reactome, http://www.reactome.org ReactomeREACT_1424 Reviewed: Vaux, D, 0000-00-00 00:00:00 tBID binds to its mitochondrial partner BAK to release cytochrome c. It has been observed in mouse systems that the activated tBID results in an allosteric activation of BAK. Activated BAX induces intramembranous oligomerization leading to a pore for cytochrome c efflux. tBID bound to inactive BAK human protein activation