Caspase-mediated cleavage of vimentin at DSVD (85) Authored: Schulze-Osthoff, K, 2008-05-18 10:00:05 EC Number: 3.4.22 Edited: Matthews, L, 2007-09-03 07:38:20 Edited: Matthews, L, 2008-05-18 16:53:19 Pubmed10469173 Pubmed11423904 Reactome Database ID Release 43201628 Reactome, http://www.reactome.org ReactomeREACT_13428 Reviewed: Ranganathan, S, 2008-06-11 19:13:33 Vimentin is cleaved by several caspases during apoptosis (Morishima et al., 1999, Byun et al., 2001). This cleavage disrupts the cytoplasmic network of intermediate filaments and coincides temporally with nuclear fragmentation. Caspase-6 recognizes and cleaves C terminal side of Asp-429. Vimentin is cleaved at Asp85 by caspases-3 and -7 (Byun et al., 2001). This clevage generates a pro-apoptotic amino-terminal cleavage product (amino acids 1-85) that amplifies the cell death signal (Byun et al., 2001).