Caspase mediated cleavage of HIP-55 Authored: Schulze-Osthoff, K, 2007-09-03 07:52:18 EC Number: 3.4.22 Edited: Matthews, L, 2007-11-11 23:40:56 HIP-55 is an actin binding SH3 domain protein that is cleaved by caspase-3. Cleavage results in dissociation of the actin-binding domain from the SH3 domain and may alter cell signaling to and from the actin cytoskeleton. In addition, this cleavage may be involved in the the alteration in cell morphology that occur during apoptosis (Chen et al., 2001). Pubmed11689006 Reactome Database ID Release 43202966 Reactome, http://www.reactome.org ReactomeREACT_12025 Reviewed: Ranganathan, S, 2007-11-23 00:10:26