Caspase mediated cleavage of vimentin at IDVD (259) Authored: Schulze-Osthoff, K, 2008-05-18 10:00:05 EC Number: 3.4.22 Edited: Matthews, L, 2007-09-03 07:38:20 Edited: Matthews, L, 2008-05-18 15:54:39 Pubmed10469173 Pubmed11423904 Reactome Database ID Release 43350319 Reactome, http://www.reactome.org ReactomeREACT_13489 Reviewed: Ranganathan, S, 2008-06-11 19:13:33 Vimentin is cleaved by several caspases during apoptosis (Morishima et al., 1999, Byun et al., 2001). This clevage disrupts the cytoplasmic network of intermediate filaments and coincides temporally with nuclear fragmentation. Asp259 is recognized and cleaved by caspase-6 (Byun et al., 2001).