Caspase-mediated cleavage of vimentin at TNLD (429) Authored: Schulze-Osthoff, K, 2008-05-18 10:00:05 EC Number: 3.4.22 Edited: Matthews, L, 2007-09-03 07:38:20 Edited: Matthews, L, 2008-05-18 15:44:16 Pubmed10469173 Pubmed11423904 Reactome Database ID Release 43350318 Reactome, http://www.reactome.org ReactomeREACT_13519 Reviewed: Ranganathan, S, 2008-06-11 19:13:33 Vimentin is cleaved by several caspases during apoptosis (Morishima et al., 1999, Byun et al., 2001). This clevage disrupts the cytoplasmic network of intermediate filaments and coincides temporally with nuclear fragmentation. Caspase-6 recognizes and cleaves C terminal side of Asp-429.