Recruited STAT5 is phosphorylated Authored: Ray, KP, 2010-05-17 EC Number: 2.7.10 Edited: Jupe, S, 2010-08-06 Pubmed10851055 Pubmed12407017 Pubmed7568001 Pubmed8631883 Reactome Database ID Release 43452097 Reactome, http://www.reactome.org ReactomeREACT_27154 Reviewed: Dooms, H, 2011-03-17 Reviewed: Villarino, A, 2011-02-11 STAT5 alpha and beta are recruited to the receptor complex and phosphorylated. JAK3 is believed to be responsible for the tyrosine phosphorylation of STAT5 in response to IL-2; it is not clear whether JAK1 is also involved (Lin & Leonard, 2000). Tyr-694 of STAT5a and Tyr-699 of STAT5b are required for IL-2 induced STAT5 activation (Lin et al. 1996). STAT5a and STAT5b are also known to be serine phophorylated in lymphocytes activated by IL-2 but the funtion of this is unclear (Xue et al. 2002). IL2:IL2R trimer p-(Y338,Y392, Y510) beta subunit:p-JAK1:JAK3:p-STAT5 IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5