Association of DFF with alpha:beta importin Authored: Matthews, L, 2008-01-29 12:03:24 Edited: Matthews, L, 2008-05-02 11:33:14 Pubmed17938174 Reactome Database ID Release 43211191 Reactome, http://www.reactome.org ReactomeREACT_13756 Reviewed: Widlak, P, 2008-05-07 23:54:18 The translocation of the DFF complex from the cytoplasm to the nucleus is mediated by the importin alfa/beta heterodimer. Both DFF40 and DFF45 possess NLS at their C-termini that interact directly with the importin alfa/beta heterodimer. However, DFF complex binds more tightly compared with the individual subunits and C-termini of both subunits are required for DFF nuclear import (Neimanis et al., 2007). DFF45:DFF40 complex importin-alpha:importin-beta DFF:associated with the importin-alpha:importin-beta complex