Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 Pubmed1833065 Pubmed18692472 Pubmed2065657 Reactome Database ID Release 43913370 Reactome, http://www.reactome.org ReactomeREACT_23992 Reviewed: Hercus, TR, 2010-09-06 Reviewed: Lopez, AF, 2010-09-06 The alpha subunit of the IL5 receptor binds IL-5 with relatively low affinity. Binding of this dimer to the common beta subunit (Bc) confers high affinity binding. Recent models of receptor activation suggest a sequential activation that is initiated by the low-affinity interaction of ligand with the alpha chain to form a binary complex. This binary complex may bind preformed Bc dimers generating a 2:2:2 hexameric complex (Hansen et al. 2008). IL3RB:JAK2 IL5 homodimer:IL5RA:Common beta chain:JAK2 IL5 homodimer:IL5RA