Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 Pubmed10477686 Pubmed1833064 Pubmed18692472 Pubmed8649415 Reactome Database ID Release 43450031 Reactome, http://www.reactome.org ReactomeREACT_23772 Reviewed: Hercus, TR, 2010-09-06 Reviewed: Lopez, AF, 2010-09-06 The alpha subunit of the IL3 receptor binds IL 3 with low affinity. Binding of this dimer to the common beta subunit (Bc) confers high affinity binding. Recent models of receptor activation suggest a sequential activation that is initiated by the low-affinity interaction of ligand with the alpha chain to form a binary complex. This binary complex is then able to bind preformed Bc dimers generating a 2:2:2 hexameric complex (Hansen et al. 2008). Covalent linkage of the receptor subunits is required for receptor signalling (Stomski et al. 1996). IL3RB:JAK2 IL3:IL3RA:IL3RB:JAK2 IL3:IL3RA