CBL binds CRK Authored: Ray, KP, 2010-05-17 Edited: Jupe, S, 2010-08-06 Pubmed8626543 Pubmed8649859 Reactome Database ID Release 43912790 Reactome, http://www.reactome.org ReactomeREACT_23925 Reviewed: Hercus, TR, 2010-09-06 Reviewed: Lopez, AF, 2010-09-06 The Crk adapter protein family is comprised of Crk-I and Crk-II, alternatively spliced products of a single gene with differing biological functions, and Crk-L, a distinct Crk-like gene product. Cbl is the dominant phosphoprotein associated with Crk in activated lymphocytes. In vitro binding indicates that the Crk SH2 domain binds Y774 of Cbl (Reedquist et al. 1996), leaving the SH3 domain of Crk free to interact with other SH3 domain-associated proteins. CRK p(Y700,731,774)-CBL:CRK