K48-polyubiquitin CBL ubiquitinates PI3K Authored: Ray, KP, 2010-05-17 Cbl is an E3 ubiquitin-protein ligase that negatively regulates signaling pathways by targeting proteins for ubiquitination and proteasomal degradation (Rao et al. 2002). Cbl-B targets PI3K for ubiquitination and degradation in T cells (Fang et al. 2000). Similarly, Cbl activation by tyrosine phosphorylation increases PI3K ubiquitination and proteasomal degradation (Dufour et al. 2008). Edited: Jupe, S, 2010-08-06 Pubmed11087752 Pubmed11994499 Pubmed18374639 Reactome Database ID Release 43912627 Reactome, http://www.reactome.org ReactomeREACT_23869 Reviewed: Hercus, TR, 2010-09-06 Reviewed: Lopez, AF, 2010-09-06 FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks