Formation of PPARA:RXRA Heterodimer at Promoters of Target Genes Authored: May, B, 2009-05-30 16:45:51 Edited: May, B, 2009-05-30 16:45:51 Edited: May, B, 2009-06-08 Peroxisome proliferator-activated receptor alpha (PPAR-alpha) is a type II nuclear receptor (its subcellular location is independent of ligand binding) related to PPAR-beta/delta and PPAR-gamma. PPAR-alpha is expressed highly in the liver where if functions to control lipid metabolism, especially fatty acid oxidation. <br>PPAR-alpha forms heterodimers with Retinoid X receptor alpha (RXR-alpha). The heterodimers bind peroxisome proliferator receptor elements (PPREs) in and around genes regulated by PPAR-alpha. Pubmed10529898 Pubmed11330046 Pubmed16476485 Pubmed16503871 Pubmed18288277 Pubmed8386511 Reactome Database ID Release 43400204 Reactome, http://www.reactome.org ReactomeREACT_19370 Reviewed: Kersten, S, 2009-06-08 Peroxisome Proliferator Receptor Element (PPRE) PPARA:RXRA Heterodimer