palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH Authored: D'Eustachio, P, 2009-03-16 18:50:14 EC Number: 2.3.1.42 Peroxisomal glyceronephosphate O-acyltransferase (GNPAT) catalyzes the reaction of palmitoyl-CoA and DHAP to form 1-palmitoyl glycerone phosphate (1-palmitoyl dihydroxyacetone phosphate) and CoASH. The active form of the enzyme is one subunit of a heterotrimer with two molecules of the alkylglycerone phosphate synthase (AGPS) enzyme (Biermann et al. 1999). It was first purified and characterized biochemically by Ofman and Wanders (1994). Mutations in the GNPAT gene are associated with rhizomelic chondrodysplasia type 2 (Ofman et al. 1998, 2001). Pubmed10215861 Pubmed11237722 Pubmed8186247 Pubmed9536089 Reactome Database ID Release 4375879 Reactome, http://www.reactome.org ReactomeREACT_15 Reviewed: Jassal, B, 2009-02-27 15:21:18