isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ Authored: D'Eustachio, P, 2009-01-07 23:39:54 EC Number: 1.1.1.42 Edited: D'Eustachio, P, 2009-01-07 23:39:54 Peroxisomal IDH1 (isocitrate dehydrogenase 1) homodimer catalyzes the reaction of isocitrate and NADP+ to form 2-oxoglutarate, CO2, and NADPH + H+. The same enzyme can also localize to the cytosol in at least some cell types (Geisbrecht and Gould 1999; Xu et al. 2004). Pubmed10521434 Pubmed15173171 Reactome Database ID Release 43389550 Reactome, http://www.reactome.org ReactomeREACT_16932 Reviewed: Jassal, B, 2009-02-27 15:21:18