Co-transport (influx) of bile salts and acids and sodium ions by ASBT A molecule of extracellular bile salt or bile acid (cholate, chenodeoxycholate, or their glycine or taurine conjugates) and a sodium ion are transported into the cytosol, mediated by ASBT (apical sodium-dependent bile acid transporter; SLC10A2) in the plasma membrane. Within the cytosol, bile salts and acids are bound to a carrier protein, FABP6 (I-BABP) (Fujita et al. 1995). Studies in a rabbit model system suggest that translocation and FABP6 binding occur as a single concerted event (Kramer et al. 1995). In the body, ASBT is expressed on the apical surfaces of enterocytes, and this reaction is the first step in the process by which bile salts and acids are reaborbed from the intestinal lumen and returned to the liver (Kullak-Ublick et al. 2004; Trauner and Boyer 2002). Authored: D'Eustachio, P, 2007-03-09 21:29:31 Edited: D'Eustachio, P, 2007-03-09 21:29:31 Pubmed12663868 Pubmed14699511 Pubmed7588781 Pubmed7864816 Pubmed9109432 Pubmed9458785 Reactome Database ID Release 43194187 Reactome, http://www.reactome.org ReactomeREACT_10050 Reviewed: D'Eustachio, P, 2007-04-30 14:43:26 bile salts and acids bile salts and acids complexed with FABP6