Transport (influx) of glycocholate and taurocholate by OATP-C A molecule of extracellular glycocholate or taurocholate is transported into the cytosol, mediated by OATP-C (SLCO1B1) in the plasma membrane. Glyco- and taurocholate exist in the blood as complexes with serum albumin, and its uptake by OATP-C must involve disruption of this complex, but the molecular mechanism coupling disruption and uptake is unknown. In the body, OATP-C is expressed on the basolateral surfaces of hepatocytes and may play a role in the uptake of glyco- and taurocholate by the liver under physiological conditions (Kullak-Ublick et al. 2004; Trauner and Boyer 2002). Authored: D'Eustachio, P, 2007-03-09 21:29:31 Edited: D'Eustachio, P, 2007-03-09 21:29:31 Pubmed10358072 Pubmed10644574 Pubmed11159893 Pubmed12663868 Pubmed14699511 Reactome Database ID Release 43194083 Reactome, http://www.reactome.org ReactomeREACT_10091 Reviewed: D'Eustachio, P, 2007-04-30 14:43:26 albumin:cholate bile salt complex cholate bile salts