Transport (influx) of bile salts and acids by OATP-A A molecule of extracellular bile salt (glyco- or taurocholate or taurochenodeoxycholate) or bile acid (cholate or chenodeoxycholate) is transported into the cytosol, mediated by OATP-A (SLCO1A2) in the plasma membrane. Bile salts and acids exist in the blood as complexes with serum albumin, and their uptake by OATP-A must involve disruption of this complex, but the molecular mechanism coupling release of a bile salt or acid from albumin to its uptake by OATP-A is unknown. In the body, OATP-A is expressed only at low levels on the basolateral surfaces of hepatocytes and may play only a minor role in the uptake of bile salts and acids by the liver (Kullak-Ublick et al. 2004; Trauner and Boyer 2002). Authored: D'Eustachio, P, 2007-03-09 21:29:31 Edited: D'Eustachio, P, 2007-03-09 21:29:31 Pubmed12663868 Pubmed14699511 Pubmed7557095 Reactome Database ID Release 43194130 Reactome, http://www.reactome.org ReactomeREACT_10072 Reviewed: D'Eustachio, P, 2007-04-30 14:43:26 albumin:bile salt and acid (OATP-A) complex bile salts and acids (OATP-A)