p-5Y-LAT:p-3Y-PLCG1:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV Phosphorylation of PLCgamma1 by p-BTK/p-SYK Authored: Garapati, P V, 2012-05-25 EC Number: 2.7.10 Edited: Garapati, P V, 2012-05-25 Pubmed11507089 Pubmed1708307 Pubmed21659545 Pubmed8657103 Reactome Database ID Release 432424487 Reactome, http://www.reactome.org ReactomeREACT_147801 Reviewed: Lanier, Lewis L, 2012-08-09 Three tyrosine residues at positions 771, 783 and 1254 in PLCgamma1 have been identified as the sites of receptor tyrosine kinase phosphorylation. Of these Y783 and Y1254 are required for PLC-gamma1 activation. <br>In myeloid cells phosphorylation of the tyrosine residues of PLC-gamma1 is mediated by SYK and BTK kinases (Ormsby et al. 2010, Kim et al. 1994, Law et al. 1996, Watanabe et al. 2001). has a Stoichiometric coefficient of 3