p-5Y-LAT:p-3Y-PLCG1:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV p-5Y-LAT:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV Release of p-PLCG1 Activated PLC-gamma1 disassociates from LAT. Membrane binding is crucial for PLC-gamma 1 activity. The PH-domain of PLC-gamma 1 binds to phosphatidylinositol 3,4,5-trisphosphate [PdtIns(3,4,5)P3], and is targeted to the membrane (Todderud et al. 1990, Wang & Wang. 2003, Kim et al. 2000). Activated PLCG1 then hydrolyses PIP2 to Inositol 1,4,5-triphosphate (IP3) and DAG Authored: Garapati, P V, 2012-05-25 Edited: Garapati, P V, 2012-05-25 Pubmed11048639 Pubmed12911816 Pubmed2374928 Reactome Database ID Release 432424485 Reactome, http://www.reactome.org ReactomeREACT_147702 Reviewed: Lanier, Lewis L, 2012-08-09