DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K DAP12 Receptors:p-DAP12:p-6Y-SYK PI3K p85 regulatory unit of PI3K binds p-6Y-SYK Authored: Garapati, P V, 2012-05-25 Edited: Garapati, P V, 2012-05-25 Phosphoinositide 3-kinases (PI3Ks) are one of the downstream effectors of activated SYK. The p85 alpha regulatory subunit of PI3K has been shown to interact with SYK phospho-tyrosine Y323. In DAP12 signaling SYK acts via the PI3K-dependent pathway to control NK cell-mediated cytotoxicity. SYK-coupled PI3K is rapidly activated and triggers a sequential activation of VAV2/VA3, RAC1, PAK1, MEK and ERK to mediate NK cell-mediated lysis (Jiang et al. 2002, Moon et al. 2005). Pubmed11907067 Pubmed15536084 Reactome Database ID Release 432424482 Reactome, http://www.reactome.org ReactomeREACT_147879 Reviewed: Lanier, Lewis L, 2012-08-09