CLM7:DAP12 Interaction of DAP12 and CLM7 Authored: Garapati, P V, 2012-05-25 CLM7/TREM5 is a member of the CMRF-35/immune receptor expressed by myeloid cell (IREM) multigene family of immune receptors expressed on myeloid cells. It has a basic residue in its transmembrane domain and a functional tyrosine-based motif in its short cytoplasmic tail. This structural arrangement confers CLM7 the ability to signal through two independent pathways: one through associating with activating adaptor protein DAP12 and the other through the tyrosine motif in its cytoplasmic tail (Martinez-Barriocanal & Sayos 2006). Edited: Garapati, P V, 2012-05-25 Pubmed16920917 Reactome Database ID Release 432426566 Reactome, http://www.reactome.org ReactomeREACT_147706 Reviewed: Lanier, Lewis L, 2012-08-09 DAP12 dimer