DAP12 receptors:DAP12 dimer DAP12 receptors:p-Y91,Y102-DAP12 dimer Phosphorylation of DAP12 Authored: Garapati, P V, 2012-05-25 Crosslinking of receptors associated with DAP12 leads to phosphorylation of tyrosine residues in their cytoplasmic ITAM by SRC family kinases (Turnbull & Colonna 2007). This initiates downstream signaling. FYN and LCK have both been found physically and functionally associated with receptors using DAP12 signaling and have been demonstrated to be involved in DAP12 phosphorylation (Mason et al. 2006). EC Number: 2.7.10 Edited: Garapati, P V, 2012-05-25 Pubmed16709819 Pubmed17220916 Reactome Database ID Release 432395439 Reactome, http://www.reactome.org ReactomeREACT_147713 Reviewed: Lanier, Lewis L, 2012-08-09 has a Stoichiometric coefficient of 4 FYN,LCK