SIGLEC14/15/16:DAP12 dimer Interaction of SIGLEC14/15/16 and DAP12 Authored: Garapati, P V, 2012-05-25 Edited: Garapati, P V, 2012-05-25 Pubmed17012248 Pubmed17483134 Pubmed18629938 Reactome Database ID Release 432172123 Reactome, http://www.reactome.org ReactomeREACT_147732 Reviewed: Lanier, Lewis L, 2012-08-09 SIGLECs are sialic acid-recognizing receptors of the immunoglobulin (Ig) superfamily expressed on immune cells. SEGLEC14 and SEGLEC15 preferentially recognise ligands containing the glycans N-acetylneuraminic acid (Neu5Ac). SEGLEC14, SEGLEC15 and SEGLEC16 are expressed by myeloid cells and associate with the activating adapter protein DAP12 via the arginine residue in their transmembrane domains (Angata et al. 2006, Angata et al. 2007, Cao et al. 2008). SIGLEC14/15/16 DAP12 dimer