DAP12:NKp44 Interaction of DAP12 and NKp44 Authored: Garapati, P V, 2012-05-25 Edited: Garapati, P V, 2012-05-25 NKp44 is a natural cytotoxicity receptor (NCR) family member selectively expressed by IL-2-activated NK cells. It is a transmembrane receptor involved in recognizing unidentified non-MHC ligands on tumor cells, mediating tumor cell lysis by activated NK cells. NKp44 is coupled to cytoplasmic signal transduction machinery via association with DAP12. Lysine-183 in the transmembrane region of NKp44 may be involved in the association with DAP12. The interaction with DAP12 influences NKp44 surface expression and hence NK cell activation (Campbell et al. 2004, Cantoni et al. 1999, Vitale et al. 1998). Pubmed10049942 Pubmed14707061 Pubmed9625766 Reactome Database ID Release 43210273 Reactome, http://www.reactome.org ReactomeREACT_147726 Reviewed: Lanier, Lewis L, 2012-08-09 DAP12 dimer