HLA-Bw4:KIR3DS1:DAP12 dimer:KIR3DS1:HLA-Bw4 KIR3DS1:HLA-Bw4 Interaction of DAP12 and KIR3DS1 Authored: Garapati, P V, 2012-05-25 Edited: Garapati, P V, 2012-05-25 Killer cell immunoglobulin-like three-domain short-tail receptor 1 (KIR3DS1) is a member of the KIR family expressed on peripheral natural killer (NK) cells and implicated in protection against HIV (Carr et al. 2007, Pascal et al. 2007). The physiological ligand for KIR3DS1 is not clearly determined but it has been suggested to bind HLA-B Bw4-80I on HIV-1-infected target cells (Qi et al. 2006). KIR3DS1 associates with DAP12 and this association enhances its cell surface expression. Crosslinking KIR3DS1 with a monoclonal antibody stimulates NK cell-mediated cytolysis and IFN-gamma production (Carr et al. 2007). Pubmed16933987 Pubmed17202323 Pubmed17641029 Reactome Database ID Release 43210298 Reactome, http://www.reactome.org ReactomeREACT_147782 Reviewed: Lanier, Lewis L, 2012-08-09 has a Stoichiometric coefficient of 2 DAP12 dimer