KIR2DS1 oligomer:HLA-C (Cw4) DAP12:KIR2DS1:HLA-Cw4 Interaction of DAP12 and KIR2DS1 Authored: Garapati, P V, 2012-05-25 Edited: Garapati, P V, 2012-05-25 Killer cell immunoglobulin-like two-domain short-tail receptor 1 (KIR2DS1) is one of the activating KIR receptors expressed on the surface of NK cells. It recognizes and binds to ligand HLA-C2:peptide complexes. KIR2DS1 oligomerizes upon interaction with its HLA-Class I ligands. The interaction between the peptide-HLA and KIR2DS1 oligomers leads to activation of the DAP12 signaling cascade. The engagement of KIR2DS1 with HLA-C2 is not sufficient to drive NK cell cytotoxicity or IFN-gamma production (Stewart et al. 2005). Recognition of HLA-C2 by KIR2DS1 is involved in the anti-leukemic activity of alloreactive NK cells and associated with protection against Hodgkin's lymphoma (Cognet et al. 2010). The presence of the HLA-C2 allele HLA-Cw6 in combination with KIR2DS1 is a major risk factor for psoriasis (Ploski et al. 2006). Pubmed16141329 Pubmed16829306 Pubmed20093094 Reactome Database ID Release 432272795 Reactome, http://www.reactome.org ReactomeREACT_147830 Reviewed: Lanier, Lewis L, 2012-08-09 DAP12 dimer