Oxidation of cortisol to yield cortisone Authored: Jassal, B, 2008-10-01 13:18:42 Cortisol and NADP+ react to form cortisone, NADPH, and H+. This reaction is catalyzed by 11beta-hydroxysteroid dehydrogenase (11beta-HSD), associated with the endoplasmic reticulum membrane. The conversion of cortisol, an active hormone, into inactive cortisone occurs in many tissues in the body, notably in the liver, and appears to play a role in regulating cortison activity. Edited: Jassal, B, 2007-04-20 21:09:56 Pubmed1885595 Reactome Database ID Release 43194023 Reactome, http://www.reactome.org ReactomeREACT_10043 Reviewed: D'Eustachio, P, 2007-04-20 21:11:21 cortisol + NADP+ => cortisone + NADPH + H+