dsRNA:RIG-I/MDA5:IPS-1:ATG5-ATG12 IPS-1:ATG5-ATG12 conjugate dsRNA:RIG-I/MDA5 Inhibition of RIG-I/MDA5 signaling by ATG5-ATG12 conjugate Authored: Garapati, P V, 2010-08-02 Autophagy protein 5 (ATG5) and autophagy-related protein 12 (ATG12) conjugate negatively regulates the type I IFN production pathway by directly associating with RIG-I/MDA5 and IPS-1 through the caspase recruitment domains (CARDs). The ATG5-ATG12 conjugate intercalates between the CARDs of RIG-I/MDA5 and IPS-1 and inhibits signal transmission, resulting in suppression of type I IFN production and innate antiviral immune responses. Edited: Garapati, P V, 2010-08-02 Pubmed17709747 Reactome Database ID Release 43936378 Reactome, http://www.reactome.org ReactomeREACT_24982 Reviewed: Kawai, T, Akira, S, 2010-10-30