IRF3-P dimer:CBP/p300 p-T,4S-IRF3:p-T,4S-IRF3 Interaction of CBP/p300 with p-IRF3 dimer Authored: Garapati, P V, 2010-08-02 Edited: Garapati, P V, 2010-08-02 Phosphorylated IRF3 dimer translocated to the nucleus interacts with the coactivator CBP/p300. This interaction prevents the export of activated IRF3 dimer from nucleus and it may also alter the conformation of the DNA binding domain of IRF3, and induce specific DNA binding of IRF3. Pubmed10082512 Pubmed9463386 Pubmed9541017 Reactome Database ID Release 431028817 Reactome, http://www.reactome.org ReactomeREACT_25275 Reviewed: Kawai, T, Akira, S, 2010-10-30 CBP/p300