IRF3-P:IRF7-P phosphorylated IRF3/IRF7 p-2S-IRF7:p-2S-IRF7 p-T,4S-IRF3:p-T,4S-IRF3 Dimerization of Phospho IRF3 or phospho IRF7 Authored: Garapati, P V, 2010-08-02 Edited: Garapati, P V, 2010-08-02 Phosphorylation of these transcription factors IRF3 and IRF7 results in a conformational change that allows their dimerization to form homo- or hetero dimers. Each of the three different combinations of dimers (IRF3:IRF3, IRF7:IRF7 and IRF3:IRF7) may selectively effect the transcription of IFN-alpha gene subfamilies and IFN-beta genes. Pubmed12604599 Reactome Database ID Release 431028821 Reactome, http://www.reactome.org ReactomeREACT_24983 Reviewed: Kawai, T, Akira, S, 2010-10-30 has a Stoichiometric coefficient of 3