dsRNA:RIG-1/MDA5:IPS-1:Ub-TRAF3 dsRNA:RIG-I/MDA5:IPS-1 K-63 polyubiquitinated TRAF3 Recruitment of TRAF3 to IPS-1 Authored: Garapati, P V, 2010-08-02 Edited: Garapati, P V, 2010-08-02 Pubmed16306936 Pubmed16858409 Pubmed17190786 Reactome Database ID Release 43918227 Reactome, http://www.reactome.org ReactomeREACT_25364 Reviewed: Kawai, T, Akira, S, 2010-10-30 TRAF3 a E3 ligase for K63-linked polyubiquitination, is one of the critical molecules required for mediating IPS-1 dependent type I IFN production. TRAF3 interacts directly with IPS-1 through the TRAF domain of TRAF3 and a TRAF-interaction motif (TIM) with in IPS-1.