dsRNA:RIG-1/MDA5:IPS-1:Ub-TRAF3:TBK1/IKKi TBK1/IKKi:SIKE1 dsRNA:RIG-1/MDA5:IPS-1:Ub-TRAF3 TBK1/IKK epsilon complex interacts with IPS-1 bound TRAF3 Authored: Garapati, P V, 2010-08-02 Edited: Garapati, P V, 2010-08-02 Pubmed16281057 Pubmed16306936 Reactome Database ID Release 43918225 Reactome, http://www.reactome.org ReactomeREACT_25051 Reviewed: Kawai, T, Akira, S, 2010-10-30 TRAF3 binds with both IPS-1 and downstream interferon regulatory factor 3/7 (IRF3/7) kinases TBK1 and IKK-epsilon (IKKi) and thus serves as a critical link between RIG-I/MDA5 adaptors and downstream regulatory kinases important for interferon regulatory factor (IRF) activation (Oganesyan et al). <br>SIKE (for Suppressor of IKKepsilon) interacts with IKKepsilon and TBK1. SIKE is associated with TBK1 under physiological condition and dissociated from TBK1 upon viral infection. Overexpression of SIKE disrupted the interactions of IKKepsilon or TBK1 with RIG-I.