dsDNA:DAI DAI binds cytosolic DNA Authored: Shamovsky, V, 2011-09-21 DAI binds to double-stranded DNA in vitro and in vivo (Wang ZC et al 2008; Takaoka A et al 2007). N-teminus of DAI contains two Z-DNA (Zalpha and Zbeta) and one B-DNA binding domains (D3 region). D3 region mediates initial binding of DAI to DNA with subsequent stabilization provided by the Zalpha and Zbeta domains. All tree DNA-binding domains are required for DAI full activation (Wang ZC et al 2008). <p>DAI was reported to form multimer upon DNA binding that might facilitate innate immune responces (Wang ZC et al 2008; Ha SC et al 2008). Edited: Shamovsky, V, 2012-02-23 Pubmed17618271 Pubmed18375758 Pubmed19095800 Pubmed21471454 Reactome Database ID Release 431591234 Reactome, http://www.reactome.org ReactomeREACT_118621 Reviewed: D'Eustachio, P, 2011-12-07 Reviewed: Upton, JW, Mocarski, ES, 2012--0-2- has a Stoichiometric coefficient of 2