TNF:TNF-R1 binds TRADD, TRAF2 and RIP Complex Authored: Williams, MG, 2007-07-11 16:49:12 Edited: Gillespie, ME, 0000-00-00 00:00:00 Once the TNF-aplha:TNF-R1:TRADD complex is formed the two TNF-alpha mediated pathways are possible. The variable is the recruitment of FADD to the larger complex formed by the TNF-aplha:TNF-R1 platform via the interaction of the Death Domains. The steps leading to the Jun, NF kappaB, or apoptotic pathways are rife with modulation. Pubmed7758105 Reactome Database ID Release 4383656 Reactome, http://www.reactome.org ReactomeREACT_2175 Reviewed: Silverman, N, Lemaitre, B, 2008-06-20 10:21:55 TNF-alpha:TNF-R1 complex TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 Complex