pro-HD5 is cleaved by trypsin Authored: Jupe, S, 2011-04-28 Edited: Jupe, S, 2011-07-27 Pro HD5 is stored and secreted from granules of Paneth cells in the small intestine (Porter et al. 1997, Cunliffe et al. 2001). The serine protease tryspin colocalizes to these granules as the inactive zymogen trypsinogen. Removal of the defensin propiece occurs extracellularly after release in to the crypt lumen, and is mediated by trypsin 2 (anionic trypsin) and/or trypsin-3 (mesotrypsin) which are converted to their active forms by enteroprotease like enzymes or by autoactivation (Ghosh et al. 2002, Ouelette 2011). Pubmed11156637 Pubmed12021776 Pubmed21560070 Pubmed9169779 Reactome Database ID Release 431461993 Reactome, http://www.reactome.org ReactomeREACT_116162 Reviewed: McDermott, AM, 2011-11-03