GAB2 is phosphorylated by p-BCR-p-FGFR1 Authored: Rothfels, K, 2012-02-09 Edited: Rothfels, K, 2012-05-16 Pubmed11739186 Pubmed12124177 Pubmed15050920 Reactome Database ID Release 431839110 Reactome, http://www.reactome.org ReactomeREACT_120831 Recruitment of GAB2 to the BCR-FGFR1 fusion protein results in GAB2 phosphorylation (Roumiatnetsev, 2004). As in the case of BCR-ABL (Sattler, 2002), recruitment and phosphorylation of GAB2 is dependent on BCR residue Y177. Deletion of Y177 abolishes GRB2 recruitment and converts the more aggressive MPD disorder induced by BCR-FGFR1 to the EMS characteristic of other FGFR1 fusions (Demiroglu, 2001; Roumianetsev, 2004) Reviewed: Ezzat, S, 2012-05-15 pY177-BCR1-p-FGFR1 mutant:GRB2:GAB2 pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB2