Phosphorylation of BCR moiety of BCR-FGFR1 Authored: Rothfels, K, 2012-02-09 EC Number: 2.7.10 Edited: Rothfels, K, 2012-05-16 Pubmed15050920 Pubmed20226962 Reactome Database ID Release 431839067 Reactome, http://www.reactome.org ReactomeREACT_121389 Reviewed: Ezzat, S, 2012-05-15 Unique among FGFR1 fusion proteins, which generally give rise to an atypical myeloproliferative syndrome (EMS) (reviewed in Jackson, 2010), the BCR-FGFR1 fusion results in a more typical chronic myeloid leukemia (CML). Although both EMS and CML activate PLCgamma signaling, and mutation of the FGFR1 Y766 PLCgamma binding site attenuates both diseases, CML-specific signaling also appears to be mediated through the BCR portion of the fusion protein. BCR Y177 binds GRB2-GAB1 and induces CML-like leukemia in mice, while expression of a Y177F BCR-FGFR1 fusion induces EMS-like disease (Roumiantsev, 2004). has a Stoichiometric coefficient of 2 BCR-p-FGFR1 fusion mutant dimer pY177-BCR-p-FGFR1 fusion mutant dimer