Recruitment of the catalytic subunit of PI3K to activated FGFR1 fusions Activation of the PI3K pathway has been demonstrated in the case of ZMYM2-FGFR1 (Chen, 2004), BCR-FGFR1 (Demiroglu, 2001) and FOP-FGFR1 (Guasch, 2001), and is presumed to occur to a greater or lesser extent in other FGFR1 fusions as well (reviewed in Jackson, 2010). Activation of the PI3K pathway suggests that the PIK3CA catalytic subunit must be recruited to the fusion protein. Authored: Rothfels, K, 2012-02-09 Edited: Rothfels, K, 2012-05-16 Pubmed11689702 Pubmed11739186 Pubmed15448205 Pubmed20226962 Reactome Database ID Release 431839080 Reactome, http://www.reactome.org ReactomeREACT_121216 Reviewed: Ezzat, S, 2012-05-15 p-FGFR1 mutant fusions:PI3K p-FGFR1 fusion mutant dimers:PIK3R1