The catalytic subunit of PI3K is recruited to the BCR-FGFR1 fusion. Activation of the PI3K pathway has been demonstrated in the case of ZMYM2-FGFR1 (Chen, 2004), BCR-FGFR1 (Demiroglu, 2001) and FOP-FGFR1 (Guasch, 2001), and is presumed to occur to a greater or lesser extent in other FGFR1 fusions as well (reviewed in Jackson, 2010). Activation of the PI3K pathway suggests that the PIK3CA catalytic subunit must be recruited to the fusion protein. Authored: Rothfels, K, 2012-02-09 Edited: Rothfels, K, 2012-05-16 Pubmed11689702 Pubmed11739186 Pubmed15448205 Pubmed20226962 Reactome Database ID Release 431839102 Reactome, http://www.reactome.org ReactomeREACT_121049 Reviewed: Ezzat, S, 2012-05-15 pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB1:PI3K p-Y177-BCR-pY-FGFR1 mutant:GRB2:p-GAB2:PIK3R1