Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding After aberrantly dimerizing in response to epithelially expressed ligands, FGFR2b S252W and P253R mutants are assumed to undergo transautophosphorylation analagous to both the wild-type receptor, although this has not been explicitly demonstrated. Transformation of NIH 3T3 cells with the FGFR2b S252W mutant confers anchorage independent growth and results in increased phosphorylation of FRS2 in a manner that depends on a functional kinase domain (Dutt, 2008). Knock-down or chemical inhibition of other FGFR2-activating mutations identified in endometrial cancer cells has been shown to cause cell death (Byron, 2008).<br><br> Authored: Rothfels, K, 2012-02-09 EC Number: 2.7.10 Edited: Rothfels, K, 2012-05-16 Pubmed18552176 Pubmed18757403 Reactome Database ID Release 432033488 Reactome, http://www.reactome.org ReactomeREACT_121230 Reviewed: Ezzat, S, 2012-05-15 has a Stoichiometric coefficient of 16 Activated FGFR2b mutants with enhanced ligand binding FGFR2b mutant dimers with enhanced ligand-binding bound to FGFs