AKT/AKT1 E17K mutant AKT inhibitors AKT inhibitors block AKT membrane recruitment AKT inhibitors bind AKT and prevent its association with the membrane, thereby blocking AKT activation (Kondapaka et al. 2003, Yap et al. 2011, Berndt et al. 2010). AKT inhibitors annotated here target all AKT isoforms (AKT1, AKT2 and AKT3). None of the annotated inhibitors are AKT E17K mutant specific and none of them have been approved for clinical use. For a recent review, please refer to Liu et al. 2009. Authored: Orlic-Milacic, M, 2012-07-18 Edited: Matthews, L, 2012-08-03 Pubmed14617782 Pubmed19644473 Pubmed20489726 Pubmed22025163 Reactome Database ID Release 432400010 Reactome, http://www.reactome.org ReactomeREACT_147895 Reviewed: Thorpe, Lauren, 2012-08-13 Reviewed: Yuzugullu, Haluk, 2012-08-13 Reviewed: Zhao, Jean J, 2012-08-13 AKT inhibitors:AKT