Conversion of PIP2 to PIP3 by PI3K associated with FGFR mutants Authored: Rothfels, K, 2012-02-09 Edited: Rothfels, K, 2012-05-16 Once recruited to the activated receptor, PI3K phosphorylates PIP2 to PIP3, leading to activation of AKT signaling. PI3K signaling has been demonstrated in ZMYM2-, FOP- and BCR-FGFR1 fusions (Chen, 2004; Demiroglu, 2001; Guasch, 2001), as well as downstream of a number of other FGFR mutants (see for instance, Byron, 2008; Kunii, 2008; Agazie, 2003; Takeda, 2007). Pubmed11689702 Pubmed11739186 Pubmed14534538 Pubmed15448205 Pubmed17505008 Pubmed18381441 Pubmed18757403 Reactome Database ID Release 431986647 Reactome, http://www.reactome.org ReactomeREACT_121187 Reviewed: Ezzat, S, 2012-05-15