FGFR mutants phosphorylate FRS2alpha After recruitment to activated FGFR mutants, FRS2alpha is believed to be phosphorylated, potentially on all 6 of the tyrosines phosphorylated by wild-type FGFRs. Phosphorylation of FRS2alpha by FGFR has been demonstrated in some cases (see for instance Qing, 2009; Bai, 2010; Ahmed, 2008; Raffioni, 1998) and is inferred to occur in others based on activation of downstream signaling modules (reviewed in Wesche, 2011; Turner and Grose, 2010). Authored: Rothfels, K, 2012-02-09 EC Number: 2.7.10 Edited: Rothfels, K, 2012-05-16 Pubmed17505008 Pubmed18373495 Pubmed19381019 Pubmed20094046 Pubmed20709759 Pubmed21666749 Pubmed21711248 Pubmed9857065 Reactome Database ID Release 431982077 Reactome, http://www.reactome.org ReactomeREACT_120797 Reviewed: Ezzat, S, 2012-05-15 has a Stoichiometric coefficient of 6 Activated FGFR mutants:p-FRS2alpha Activated FGFR mutants:FRS2alpha