FGFR4 kinase mutants are inhibited by PD170734 Authored: Rothfels, K, 2012-02-09 Edited: Rothfels, K, 2012-05-16 Pubmed19809159 Reactome Database ID Release 432046363 Reactome, http://www.reactome.org ReactomeREACT_120902 Reviewed: Ezzat, S, 2012-05-15 Treatment of cells expressing FGFR4 N535K or V550E with the in vitro FGFR inhibitor PD170734 reduces the levels of receptor autophosphorylation and increases the activation of caspase-3 and the number of cells undergoing apoptosis (Taylor, 2009). has a Stoichiometric coefficient of 2 FGFR4 enhanced kinase mutant dimers FGFR4 mutant dimers with enhanced kinase activity:PD173074