Activated FGFR mutants Activated FGFR mutants bind PLC-gamma Although it has not been rigourously established, there is some evidence that PLC-gamma signaling may be activated after autophosphorylation of some FGFR mutants, analagous to the wild type receptor (see for instance, Hart, 2000; Chen, 2005; Cha, 2008; di Martino, 2009; Gartside, 2009; Cross, 2000; Hatch, 2006). The extent to which each of the mutants activates this pathway and to which proliferation and tumorigenesis relies on PLC-gamma dependent signaling, remains to be more firmly established. Authored: Rothfels, K, 2012-02-09 Edited: Rothfels, K, 2012-05-16 Pubmed10652257 Pubmed10918587 Pubmed16091734 Pubmed16844695 Pubmed18337450 Pubmed19147536 Pubmed19749790 Reactome Database ID Release 432077380 Reactome, http://www.reactome.org ReactomeREACT_121127 Reviewed: Ezzat, S, 2012-05-15 Activated FGFR mutants bound to PLC-gamma