AKT1 E17K mutant binds PIP2 Authored: Orlic-Milacic, M, 2012-07-18 Edited: Matthews, L, 2012-08-03 Pubmed17611497 Pubmed18954143 Reactome Database ID Release 432219536 Reactome, http://www.reactome.org ReactomeREACT_147896 Reviewed: Thorpe, Lauren, 2012-08-13 Reviewed: Yuzugullu, Haluk, 2012-08-13 Reviewed: Zhao, Jean J, 2012-08-13 Substitution of glutamic acid with lysine at position 17 of AKT1 results in constitutive plasma membrane localization of AKT1, independent of PI3K activity and PIP3 generation (Carpten et al. 2007). This constitutive plasma membrane targeting of AKT1 E17K mutant is due to an increased affinity for PIP2 (Landgraf et al. 2008). AKT1 E17K mutant:PIP2